Danio
The potential of zebrafish as a comparative model in behavioural
neuroscience is currently hampered only by the lack of reliable and
validated behavioural assays available to researchers. In the present
experiment, we describe the performance of zebrafish in a test of
attentional set formation. The fish were initially trained on a
two-choice colour discrimination. Upon reaching acquisition criterion,
the reinforced alternative was switched to the previously unreinforced
alternative. Again, upon reaching criterion, the cues were replaced with
a novel pair of colours (intra-dimensional shift) and reversed again on
reaching criteria. We found that zebrafish show a steady decrease in
trials-to-criteria over the four phases of the experiment, suggesting
that they are forming and maintaining an attentional set, as has
previously been demonstrated with mammals. Reversal learning deficits
have been implicated in a variety of human psychological disorders
(e.g., disorders of impulse control) and as such, we propose that
performance of zebrafish in this procedure may represent a useful
comparative model to complement existing rodent models.
Danio
Danio
Danio
Danio
Danio
Danio
Danio
Danio
No comments:
Post a Comment