Lidoderm Patch
Due to safety concerns regarding the entire COX-II inhibitor class in
the fall of 2004, the sponsor of the study, Endo Pharmaceuticals Inc.,
voluntarily elected to prematurely halt the study prior to reaching the
original enrollment target. However an analysis of data after six weeks
of treatment showed that of the patients treated in the Lidoderm group
(N=56), 54% experienced a 30% or greater improvement in average daily
pain intensity; (studies have reported that 30% or greater reductions in
pain intensity are clinically meaningful to pain patients). In the
Celebrex group (N=63), 62% experienced a 30% or greater improvement in
average daily pain intensity. In addition, clinically meaningful
reductions in pain were noted in both treatment groups at week 12.
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