Capsaicin Cream
The relationship between learning capability and neurological damage
following neonatal treatment with capsaicin (50 mg/kg) was studied in
adult Wistar rats of either sex using different experimental procedures.
First of all, the reaction to a stress-inducing situation was evaluated
by analysing the behavior of capsaicin and vehicle-treated rats in an
open field situation. No differences were observed between these two
groups. Moreover, the parameters considered were similar to those of
untreated, age-matched animals. Rats treated with capsaicin showed a
marked learning impairment of an appetitive task in a complex maze. On
the contrary, no alterations were observed in both retention and
extinction of this conditioned behavior. In spatial discrimination
investigated using a different maze (8-arm radial maze) but with the
same reinforcement (food), no difference was found between capsaicin-and
vehicle-treated rats. In both groups a trial number-related increase of
the responding efficiency and a decrease in the mean running time were
observed. Neonatally treated rats behaved also similarly in aversive
conditioning. However, their learning performances were much better than
those of untreated rats. These results confirm that neonatal exposure
to painful stimuli later improves active avoidance performance.
Capsaicin treatment did not have any effect on the latency of
nociceptive response in the hot-plate test.
Capsaicin Cream
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